| http://purl.uniprot.org/citations/15827085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15827085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15827085 | http://www.w3.org/2000/01/rdf-schema#comment | "Precise spatial and temporal regulation of Rho GTPases is required in controlling F-actin-based changes in cell morphology. The molecular mechanisms through which microtubules (MTs) modulate the activity of RhoGTPases and regulate the actin cytoskeleton are unclear. Here we show that p21-activated-kinase 4 (PAK4) mediates morphological changes through its association with the Rho-family guanine nucleotide exchange factor (GEF), GEF-H1. We show that this association is dependent upon a novel GEF-H1 interaction domain (GID) within PAK4. Further, we show that PAK4-mediated phosphorylation of Ser810 acts as a switch to block GEF-H1-dependent stress fiber formation while promoting the formation of lamellipodia in NIH-3T3 cells. We found that the endogenous PAK4-GEF-H1 complex associates with MTs and that PAK4 phosphorylation of MT-bound GEF-H1 releases it into the cytoplasm of NIH-3T3 cells, which coincides with the dissolution of stress fibers. Our observations propose a novel role for PAK4 in GEF-H1-dependent crosstalk between MTs and the actin cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02313"xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02313"xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Zozulya S."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Zozulya S."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Callow M.G."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Callow M.G."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Gishizky M.L."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Gishizky M.L."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Jallal B."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Jallal B."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Smeal T."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/author | "Smeal T."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/pages | "1861-1872"xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/pages | "1861-1872"xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/title | "PAK4 mediates morphological changes through the regulation of GEF-H1."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/title | "PAK4 mediates morphological changes through the regulation of GEF-H1."xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/15827085 | http://purl.uniprot.org/core/volume | "118"xsd:string |