| http://purl.uniprot.org/citations/15827121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15827121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15827121 | http://www.w3.org/2000/01/rdf-schema#comment | "We have created a stable transgenic rag2-EGFP-mMyc zebrafish line that develops GFP-labeled T cell acute lymphoblastic leukemia (T-ALL), allowing visualization of the onset and spread of this disease. Here, we show that leukemias from this transgenic line are highly penetrant and render animals moribund by 80.7 +/-17.6 days of life (+/-1 SD, range = 50-158 days). These T cell leukemias are clonally aneuploid, can be transplanted into irradiated recipient fish, and express the zebrafish orthologues of the human T-ALL oncogenes tal1/scl and lmo2, thus providing an animal model for the most prevalent molecular subgroup of human T-ALL. Because T-ALL develops very rapidly in rag2-EGFP-mMyc transgenic fish (in which "mMyc" represents mouse c-Myc), this line can only be maintained by in vitro fertilization. Thus, we have created a conditional transgene in which the EGFP-mMyc oncogene is preceded by a loxed dsRED2 gene and have generated stable rag2-loxP-dsRED2-loxP-EGFP-mMyc transgenic zebrafish lines, which have red fluorescent thymocytes and do not develop leukemia. Transgenic progeny from one of these lines can be induced to develop T-ALL by injecting Cre RNA into one-cell-stage embryos, demonstrating the utility of the Cre/lox system in the zebrafish and providing an essential step in preparing this model for chemical and genetic screens designed to identify modifiers of Myc-induced T-ALL."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0408708102"xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0408708102"xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Feng H."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Feng H."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Kutok J.L."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Kutok J.L."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Kanki J.P."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Kanki J.P."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Look A.T."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Look A.T."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Langenau D.M."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Langenau D.M."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Berghmans S."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/author | "Berghmans S."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/pages | "6068-6073"xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/pages | "6068-6073"xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/title | "Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia."xsd:string |
| http://purl.uniprot.org/citations/15827121 | http://purl.uniprot.org/core/title | "Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia."xsd:string |