| http://purl.uniprot.org/citations/15828871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15828871 | http://www.w3.org/2000/01/rdf-schema#comment | "Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (signal-transducing adaptor molecule) form a heterodimeric complex that associates with endosomal membranes and is tyrosine-phosphorylated in response to a variety of growth factors including EGF (epidermal growth factor), HGF (hepatocyte growth factor) and PDGF (platelet-derived growth factor). Phosphorylation of the Hrs-STAM complex requires receptor endocytosis. We show that an intact UIM (ubiquitin interaction motif) within Hrs is a conserved requirement for Hrs phosphorylation downstream of both EGF and HGF stimulations. Consistent with this, expression of a dominant-negative form of the E3 ubiquitin ligase, c-Cbl, inhibits EGF- and HGF-dependent Hrs phosphorylation. Despite this conservation, kinase inhibitor profiles using PP1 (4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine) and SU6656 indicate that distinct non-receptor tyrosine kinases couple EGF, HGF and PDGF stimulation with the tyrosine phosphorylation of the Hrs-STAM complex. Crucially, analysis with phospho-specific antibodies indicates that these kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element."xsd:string |
| http://purl.uniprot.org/citations/15828871 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20050067"xsd:string |
| http://purl.uniprot.org/citations/15828871 | http://purl.uniprot.org/core/author | "Urbe S."xsd:string |
| http://purl.uniprot.org/citations/15828871 | http://purl.uniprot.org/core/author | "Clague M.J."xsd:string |
| http://purl.uniprot.org/citations/15828871 | http://purl.uniprot.org/core/author | "Row P.E."xsd:string |
| http://purl.uniprot.org/citations/15828871 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15828871 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/15828871 | http://purl.uniprot.org/core/pages | "629-636"xsd:string |
| http://purl.uniprot.org/citations/15828871 | http://purl.uniprot.org/core/title | "Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties."xsd:string |
| http://purl.uniprot.org/citations/15828871 | http://purl.uniprot.org/core/volume | "389"xsd:string |
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