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http://purl.uniprot.org/citations/15834029http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15834029http://www.w3.org/2000/01/rdf-schema#comment"

Background

A recent study showed that transforming growth factor-beta1 (TGF-beta1) induces amyloid-beta deposition in cerebral blood vessels and meninges of a transgenic mouse model of Alzheimer's disease (AD), and that TGF-beta1 mRNA levels are correlated with cerebral amyloid angiopathy (CAA) in human AD brains. A T/C polymorphism at codon 10 in exon 1 of the TGF-beta1 gene has been reported to be associated with the serum TGF-beta1 concentration. We investigated whether the TGF-beta1 polymorphism is associated with the risk of CAA.

Methods

The association between the severity of CAA and the T/C polymorphism at codon 10 in exon 1 of the TGF-beta1 was investigated in 167 elderly Japanese autopsy cases, including 73 patients with AD. The apolipoprotein E (APOE) genotype was also determined.

Results

The genotypes (TT/ TC/ CC) were associated with the severity of CAA significantly in all patients (p = 0.0026), in non-AD patients (p = 0.011), and APOE non-epsilon4 carriers (p = 0.0099), but not in AD patients or APOE epsilon4 carriers. The number of the T alleles positively correlated with the severity of CAA in all patients (p = 0.0011), non-AD patients (p = 0.0026), and APOE non-epsilon4 carriers (p = 0.0028), but not in AD patients or APOE epsilon4 carriers. The polymorphism was not significantly associated with AD.

Conclusions

Our results suggest that the polymorphism in TGF-beta1 is associated with the severity of CAA, especially in non-AD patients and APOE non-epsilon4 carriers."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.org/dc/terms/identifier"doi:10.1136/jnnp.2003.034454"xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/author"Matsushita M."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/author"Yamada M."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/author"Itoh Y."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/author"Takahashi A."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/author"Hamaguchi T."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/author"Mizusawa H."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/author"Okino S."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/author"Otomo E."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/author"Sodeyama N."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/name"J Neurol Neurosurg Psychiatry"xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/pages"696-699"xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/title"Association of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy."xsd:string
http://purl.uniprot.org/citations/15834029http://purl.uniprot.org/core/volume"76"xsd:string
http://purl.uniprot.org/citations/15834029http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15834029
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