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http://purl.uniprot.org/citations/15837310http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15837310http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15837310http://www.w3.org/2000/01/rdf-schema#comment"4-Aryl-5-pyrimidyl based cytokine synthesis inhibitors that contain a novel monocyclic, pyrazolone heterocyclic core are described. Many of these inhibitors showed low nanomolar activity against LPS-induced TNF-alpha production. One of the compounds (6e) was found to be efficacious in the rat iodoacetate (RIA) in vivo model of osteoarthritis. The X-ray crystal structure of a pyrazolone inhibitor cocrystallized with mutated p38 (mp38) is presented."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.org/dc/terms/identifier"doi:10.1016/j.bmcl.2005.03.007"xsd:string
http://purl.uniprot.org/citations/15837310http://purl.org/dc/terms/identifier"doi:10.1016/j.bmcl.2005.03.007"xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Walter R.L."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Walter R.L."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Bookland R.G."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Bookland R.G."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"De B."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"De B."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Djung J.F."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Djung J.F."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Brugel T.A."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Brugel T.A."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Golebiowski A."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Golebiowski A."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Hsieh L.C."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Hsieh L.C."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Janusz M.J."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Janusz M.J."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Laufersweiler M.J."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Laufersweiler M.J."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Mekel M.J."xsd:string
http://purl.uniprot.org/citations/15837310http://purl.uniprot.org/core/author"Mekel M.J."xsd:string