| http://purl.uniprot.org/citations/15838253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15838253 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to investigate a possible protective role of a selective endothelin-A receptor antagonist on hepatic microcirculation after ischemia/reperfusion. In a rat model, warm ischemia of the left liver lobe was induced for 90 minutes under intraperitoneal anesthesia with xylazine and ketamine. Shamoperated and untreated ischemic groups and a group treated with BSF 208075 were investigated. The effect of the endothelin-A receptor antagonist on ischemia/reperfusion was assessed by in-vivo microscopy and measurement of aspartate aminotransferase and alanine aminotransferase levels. In the untreated group, sinusoidal constriction to 70% of basal diameters was observed, leading to a significant decrease in perfusion rate. In addition, we found an increased percentage of stagnant leukocytes and platelets in sinusoids and in postsinusoidal venules (P < 0.05). A significant increase in liver enzymes was detected 6 hours after reperfusion (P < 0.05). In the treatment group, sinusoidal diameters were maintained at 108%, and perfusion rate was significantly increased (P < 0.05). Hepatocellular damage was decreased and leukocyte and platelet-endothelium interactions were reduced (P < 0.05). Our results provide evidence that the new therapeutic approach using an endothelin-A receptor antagonist is effective in reducing hepatic ischemia/reperfusion injury. It could be shown for the first time that endothelin receptor blockade also influences platelet-endothelium interactions."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.org/dc/terms/identifier | "doi:10.1097/01.fjc.0000166231.26583.b1"xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/author | "Ludwig S."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/author | "Witzigmann H."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/author | "Glasser S."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/author | "Hauss J."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/author | "Uhlmann D."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/author | "Gaebel G."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/author | "Lauer H."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/author | "Serr F."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/name | "J Cardiovasc Pharmacol 44 Suppl"xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/pages | "S103-4"xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/title | "Endothelin-A receptor blockade improves postischemic hepatic microhemodynamics."xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/15838253 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15838253 |
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| http://purl.uniprot.org/uniprot/#_P26684-mappedCitation-15838253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15838253 |