| http://purl.uniprot.org/citations/15838256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15838256 | http://www.w3.org/2000/01/rdf-schema#comment | "Spontaneously hypertensive stroke-prone rats (SHR-SP) suffer spontaneous stroke in part as a result of abnormal cerebrovascular development. Reduction of regional cerebral blood flow in this model has already been demonstrated. This model has three distinct stages of hypertension: pre-hypertensive, typical hypertensive and malignant hypertensive. We investigated the level of endothelin-1 and its receptor expression in the frontal cortex of SHR-SP at the malignant hypertensive stage (35-40 weeks of age), during which time the rats suffer strokes. The cerebral endothelin-1 level, as determined by enzyme-linked immunosorbent assay, was highly increased at this severely hypertensive stage compared to their genetic control, normotensive Wistar-Kyoto rats. This upregulation was associated with an increased expression of endothelin-A receptor, however, another endothelin-1 receptor, endothelin-B, was downregulated. The regional cerebral blood flow in the frontal cortex was reduced by 60% in 40-week-old malignantly SHR-SP as compared to age-matched Wistar-Kyoto rats. Thus, cerebral endothelin-1 expression increased in malignant hypertension in SHR-SP. The enhanced endothelin-1 may activate the endothelin-A receptor, which would, in turn, result in reduced cerebral blood flow. Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.org/dc/terms/identifier | "doi:10.1097/01.fjc.0000166224.57970.91"xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/author | "Yoshioka M."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/author | "Ueno K."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/author | "Kitabatake A."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/author | "Hattori Y."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/author | "Miyauchi T."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/author | "Togashi H."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/author | "Sakuma I."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/author | "Jesmin S."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/name | "J Cardiovasc Pharmacol 44 Suppl"xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/pages | "S11-5"xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/title | "Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage."xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/15838256 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15838256 |
| http://purl.uniprot.org/citations/15838256 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15838256 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JSX5-mappedCitation-15838256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15838256 |
| http://purl.uniprot.org/uniprot/#_A6J756-mappedCitation-15838256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15838256 |
| http://purl.uniprot.org/uniprot/#_A1Y2B8-mappedCitation-15838256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15838256 |
| http://purl.uniprot.org/uniprot/#_A1Y2R7-mappedCitation-15838256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15838256 |
| http://purl.uniprot.org/uniprot/#_A1Y2R8-mappedCitation-15838256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15838256 |
| http://purl.uniprot.org/uniprot/#_A1Y2R9-mappedCitation-15838256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15838256 |