| http://purl.uniprot.org/citations/15838363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15838363 | http://www.w3.org/2000/01/rdf-schema#comment | "We hypothesize that endothelin-A receptor stimulation contributes to the elevated blood pressure and superoxide production in endothelin-B receptor-deficient rats on a high salt diet. Experiments were conducted on homozygous endothelin-B-deficient (sl/sl) and wild-type rats (wt) fed a high salt diet (8% NaCl) for 3 weeks. Separate groups were given normal drinking water or water containing the endothelin-A receptor antagonist, ABT-627 (5 mg/kg per day; n = 8-9 in all groups). On a normal salt diet, (sl/sl) rats had a significantly elevated systolic blood pressure compared with wt (138 +/- 3 vs 117 +/-4 mmHg, respectively; P < 0.05). High salt diet caused a significant increase in systolic blood pressure in (sl/sl) rats compared with wt (158 +/- 2 vs 138 +/-3 mmHg, respectively; P < 0.05). Endothelin-A receptor blockade decreased systolic blood pressure in (sl/sl) rats on high salt (125 +/-5 mmHg; P < 0.05 vs without antagonist) without affecting the systolic blood pressure in wt (119 +/-4 mmHg). Aortic superoxide production (lucigenin chemiluminescence) and plasma 8-isoprostane were elevated in sl/sl rats and were significantly reduced by endothelin-A receptor blockade in sl/sl, but not in wt rats. These findings suggest that endothelin-1, through the endothelin-A receptor, contributes to salt-induced hypertension and vascular superoxide production in endothelin-B-deficient rats."xsd:string |
| http://purl.uniprot.org/citations/15838363 | http://purl.org/dc/terms/identifier | "doi:10.1097/01.fjc.0000166205.66555.40"xsd:string |
| http://purl.uniprot.org/citations/15838363 | http://purl.uniprot.org/core/author | "Pollock J.S."xsd:string |
| http://purl.uniprot.org/citations/15838363 | http://purl.uniprot.org/core/author | "Pollock D.M."xsd:string |
| http://purl.uniprot.org/citations/15838363 | http://purl.uniprot.org/core/author | "Dabbs Loomis E."xsd:string |
| http://purl.uniprot.org/citations/15838363 | http://purl.uniprot.org/core/author | "Elmarakby A.A."xsd:string |
| http://purl.uniprot.org/citations/15838363 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15838363 | http://purl.uniprot.org/core/name | "J Cardiovasc Pharmacol 44 Suppl"xsd:string |
| http://purl.uniprot.org/citations/15838363 | http://purl.uniprot.org/core/pages | "S7-10"xsd:string |
| http://purl.uniprot.org/citations/15838363 | http://purl.uniprot.org/core/title | "ETA receptor blockade attenuates hypertension and decreases reactive oxygen species in ETB receptor-deficient rats."xsd:string |
| http://purl.uniprot.org/citations/15838363 | http://purl.uniprot.org/core/volume | "1"xsd:string |
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