| http://purl.uniprot.org/citations/15838535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15838535 | http://www.w3.org/2000/01/rdf-schema#comment | "The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis of a large Scottish family in which a t(1;11) translocation cosegregates with schizophrenia, bipolar disorder and recurrent major depression. We now report evidence for association between bipolar disorder and schizophrenia and this locus in the general Scottish population. A systematic study of linkage disequilibrium in a representative sample of the Scottish population was undertaken across the 510 kb of TRAX and DISC1. SNPs representing each haplotype block were selected for case-control association studies of both schizophrenia and bipolar disorder. Significant association with bipolar disorder in women P=0.00026 (P=0.0016 in men and women combined) was detected in a region of DISC1. This same region also showed nominally significant association with schizophrenia in both men and women combined, P=0.0056. Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01. Only the association between bipolar women and DISC1 remained significant after correction for multiple testing. This result provides further supporting evidence for DISC1 as a susceptibility factor for both bipolar disorder and schizophrenia, consistent with the diagnoses in the original Scottish translocation family."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.mp.4001669"xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/author | "Evans K.L."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/author | "Blackwood D.H."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/author | "Muir W.J."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/author | "Porteous D.J."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/author | "Condie A."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/author | "Millar J.K."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/author | "Thomson P.A."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/author | "Wray N.R."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/author | "Hellard S.L."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/name | "Mol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/pages | "657-668"xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/title | "Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population."xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/15838535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15838535 |
| http://purl.uniprot.org/citations/15838535 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15838535 |
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| http://purl.uniprot.org/uniprot/#_C4P093-mappedCitation-15838535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15838535 |
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| http://purl.uniprot.org/uniprot/#_C4P098-mappedCitation-15838535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15838535 |