| http://purl.uniprot.org/citations/15841212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15841212 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptopodin is the founding member of a novel class of proline-rich actin-associated proteins highly expressed in telencephalic dendrites and renal podocytes. Synaptopodin-deficient (synpo(-/-)) mice lack the dendritic spine apparatus and display impaired activity-dependent long-term synaptic plasticity. In contrast, the ultrastructure of podocytes in synpo(-/-) mice is normal. Here we show that synpo(-/-) mice display impaired recovery from protamine sulfate-induced podocyte foot process (FP) effacement and LPS-induced nephrotic syndrome. Similarly, synpo(-/-) podocytes show impaired actin filament reformation in vitro. We further demonstrate that synaptopodin exists in 3 isoforms, neuronal Synpo-short (685 AA), renal Synpo-long (903 AA), and Synpo-T (181 AA). The C terminus of Synpo-long is identical to that of Synpo-T. All 3 isoforms specifically interact with alpha-actinin and elongate alpha-actinin-induced actin filaments. synpo(-/-) mice lack Synpo-short and Synpo-long expression but show an upregulation of Synpo-T protein expression in podocytes, though not in the brain. Gene silencing of Synpo-T abrogates stress-fiber formation in synpo(-/-) podocytes, demonstrating that Synpo-T serves as a backup for Synpo-long in synpo(-/-) podocytes. In concert, synaptopodin regulates the actin-bundling activity of alpha-actinin in highly dynamic cell compartments, such as podocyte FPs and the dendritic spine apparatus."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci23371"xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/author | "Faul C."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/author | "Reiser J."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/author | "Mundel P."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/author | "Oh J."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/author | "Asanuma K."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/author | "Giardino L."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/author | "Chabanis S."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/pages | "1188-1198"xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/title | "Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner."xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/15841212 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15841212 |
| http://purl.uniprot.org/citations/15841212 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15841212 |
| http://purl.uniprot.org/uniprot/P57780#attribution-217C02FA37C4022CA31539C59CAEF5AA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15841212 |
| http://purl.uniprot.org/uniprot/P35609#attribution-0D86E7C323A040A08C75A278CC30C6CA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15841212 |
| http://purl.uniprot.org/uniprot/Q7TPR4#attribution-0D86E7C323A040A08C75A278CC30C6CA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15841212 |
| http://purl.uniprot.org/uniprot/Q8CC35#attribution-10458991375782D92C1FE61F930D4EE8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15841212 |
| http://purl.uniprot.org/uniprot/Q8CC35#attribution-217C02FA37C4022CA31539C59CAEF5AA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15841212 |
| http://purl.uniprot.org/uniprot/Q8N3V7#attribution-0D86E7C323A040A08C75A278CC30C6CA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15841212 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SV25-mappedCitation-15841212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15841212 |