| http://purl.uniprot.org/citations/15843557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15843557 | http://www.w3.org/2000/01/rdf-schema#comment | "Stimulation of the TCR leads to an oscillatory release of free calcium that activates members of the calcium/calmodulin-dependent protein kinase II (CaMKII) family. The CaMKII molecules have profound and lasting effects on cellular signaling in several cell types, yet the role of CaMKII in T cells is still poorly characterized. In this report we describe a splice variant of CaMKIIbeta, CaMKIIbeta'e, in mouse T cells. We have determined its function, along with that of CaMKIIgamma, by introducing the active and kinase-dead mutants into activated P14 TCR transgenic T cells using retroviral transduction. Active CaMKII enhanced the proliferation and cytotoxic activity of T cells while reducing their IL-2 production. Furthermore, it induced a profound state of unresponsiveness that could be overcome only by prolonged culture in IL-2. These results indicate that members of the CaMKII family play an important role in regulation of CD8 T cell proliferation, cytotoxic effector function, and the response to restimulation."xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.9.5583"xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/author | "Lin M.Y."xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/author | "Hedrick S.M."xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/author | "Zal T."xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/author | "Ch'en I.L."xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/author | "Gascoigne N.R."xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/pages | "5583-5592"xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/title | "A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness."xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15843557 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15843557 |
| http://purl.uniprot.org/citations/15843557 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15843557 |
| http://purl.uniprot.org/uniprot/#_Q3TY93-mappedCitation-15843557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15843557 |
| http://purl.uniprot.org/uniprot/#_Q8BL41-mappedCitation-15843557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15843557 |
| http://purl.uniprot.org/uniprot/#_Q5SVI2-mappedCitation-15843557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15843557 |
| http://purl.uniprot.org/uniprot/#_Q5SVJ0-mappedCitation-15843557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15843557 |
| http://purl.uniprot.org/uniprot/#_P28652-mappedCitation-15843557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15843557 |
| http://purl.uniprot.org/uniprot/#_Q68EG2-mappedCitation-15843557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15843557 |
| http://purl.uniprot.org/uniprot/#_Q8K4W4-mappedCitation-15843557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15843557 |
| http://purl.uniprot.org/uniprot/#_Q8K4W5-mappedCitation-15843557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15843557 |
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