| http://purl.uniprot.org/citations/15848195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15848195 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe the regulation mechanisms of the Na(+)-dependent neutral amino acid transporter ASCT2 via nitric oxide (NO) in the human intestinal cell line, Caco-2. Exposure of Caco-2 cells to S-nitrosothiol, such as S-nitroso-N-acetyl-DL-penicillamine (SNAP) and S-nitrosoglutathione, and the NO-donor, NOC12, concentration- and time-dependently increased Na(+)-dependent alanine uptake. Kinetic analyses indicated that SNAP increases the maximal velocity (V(max)) of Na(+)-dependent alanine uptake in Caco-2 cells without affecting the Michaelis-Menten constant (K(t)). The stimulatory effect was partially eliminated by actinomycin D and cycloheximide. Increased Na(+)-dependent alanine uptake by SNAP was partially abolished by the NO scavengers, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide sodium salt (carboxy-PTIO) and N-(dithiocarboxy)sarcosine disodium salts (DTCS), as well as the NADPH oxidase inhibitor, diphenyleneiodonium. RT-PCR revealed that Caco-2 cells expressed the Na(+)-dependent neutral amino acid transporter ASCT2, but not the other Na(+)-dependent neutral amino acid transporters ATB(0,+) and B(0)AT1. These results suggested that functional up-regulation of ASCT2 by SNAP might be partially associated with an increase in the density of transporter protein via de novo synthesis."xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.03.065"xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/author | "Matsuda Y."xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/author | "Takahashi S."xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/author | "Wada M."xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/author | "Uchiyama T."xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/pages | "2499-2506"xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/title | "Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells."xsd:string |
| http://purl.uniprot.org/citations/15848195 | http://purl.uniprot.org/core/volume | "579"xsd:string |
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