| http://purl.uniprot.org/citations/15849194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15849194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15849194 | http://www.w3.org/2000/01/rdf-schema#comment | "Raf-1 protects cells from apoptosis, independently of its signals to MEK and ERK, by translocating to the mitochondria where it binds Bcl-2 and displaces BAD. However, the answer to the question of how Raf-1 is normally lured to the mitochondria and becomes activated remains elusive. p21-activated protein kinases (Paks) are serine/threonine protein kinases that phosphorylate Raf-1 at Ser-338 and Ser-339. Here we elucidate the molecular mechanism through which Pak1 signals to BAD through a Raf-1-activated pathway. Upon phosphorylation by Pak1, Raf-1 translocates to mitochondria and phosphorylates BAD at Ser-112. Moreover, the mitochondrial translocation of Raf-1 and the interaction between Raf-1 and Bcl-2 are regulated by Raf-1 phosphorylation at Ser-338/Ser-339. Notably, we show that formation of a Raf-1-Bcl-2 complex coincides with loss of an interaction between Bcl-2 and BAD. These signals are specific for Pak1, because Src-activated Raf-1 only stimulates the MAP kinase cascade. Thus, our data identify the molecular connections of a Pak1-Raf-1-BAD pathway that is involved in cell survival signaling."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m413374200"xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m413374200"xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/author | "Jin S."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/author | "Jin S."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/author | "Field J."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/author | "Field J."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/author | "Zhuo Y."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/author | "Zhuo Y."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/pages | "24698-24705"xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/pages | "24698-24705"xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/title | "p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/title | "p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association."xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15849194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15849194 |
| http://purl.uniprot.org/citations/15849194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15849194 |