| http://purl.uniprot.org/citations/15850793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15850793 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, we have shown that SOCS-1/3 overexpression in hepatic cells abrogates signaling of type I interferons (IFN) which may contribute to the frequently observed IFN resistance of hepatitis C virus (HCV). IFN-lambdas (IL-28A/B and IL-29), a novel group of IFNs, also efficiently inhibit HCV replication in vitro with potentially less hematopoietic side effects than IFN-alpha because of limited receptor expression in hematopoietic cells. To further evaluate the potential of IFN-lambdas in chronic viral hepatitis, we examined the influence of SOCS protein expression on IFN-lambda signaling. First, we show that hepatic cell lines express the IFN-lambda receptor complex consisting of IFN-lambdaR1 (IL-28R1) and IL-10R2. Whereas in mock-transfected HepG2 cells, IL-28A and IL-29 induced STAT1 and STAT3 phosphorylation, overexpression of SOCS-1 completely abrogated IL-28A and IL-29-induced STAT1/3 phosphorylation. Similarly, IL-28A and IL-29 induced mRNA expression of the antiviral proteins 2',5'-OAS and MxA was abolished by overexpression of SOCS-1. In conclusion, we assume that despite antiviral properties of IFN-lambdas, their efficacy as antiviral agents may have similar limitations as IFN-alpha due to inhibition by SOCS proteins."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.04.004"xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Eichhorst S.T."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Olszak T."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Goke B."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Brand S."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Auernhammer C.J."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Beigel F."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Dambacher J."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Diepolder H."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Zitzmann K."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/author | "Vlotides G."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/pages | "543-548"xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/title | "SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29."xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://purl.uniprot.org/core/volume | "331"xsd:string |
| http://purl.uniprot.org/citations/15850793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15850793 |
| http://purl.uniprot.org/citations/15850793 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15850793 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C362-mappedCitation-15850793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15850793 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C391-mappedCitation-15850793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15850793 |
| http://purl.uniprot.org/uniprot/#_A7YIG8-mappedCitation-15850793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15850793 |
| http://purl.uniprot.org/uniprot/#_A0A7H1MG84-mappedCitation-15850793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15850793 |
| http://purl.uniprot.org/uniprot/#_A0A7H1MG85-mappedCitation-15850793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15850793 |