| http://purl.uniprot.org/citations/15851468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15851468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15851468 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone morphogenetic proteins (BMPs), a subset of the transforming growth factor (TGF)-beta superfamily, regulate a diverse array of cellular functions during development and in the adult. BMP-9 (also known as growth and differentiation factor (GDF)-2) potently induces osteogenesis and chondrogenesis, has been implicated in the differentiation of cholinergic neurons, and may help regulate glucose metabolism. We have determined the structure of BMP-9 to 2.3 A and examined the differences between our model and existing crystal structures of other BMPs, both in isolation and in complex with their receptors. TGF-beta ligands are translated as precursors, with pro-regions that generally dissociate after cleavage from the ligand, but in some cases (including GDF-8 and TGF-beta1, -2, and -3), the pro-region remains associated after secretion from the cell and inhibits binding of the ligand to its receptor. Although the proregion of BMP-9 remains tightly associated after secretion, we find, in several cell-based assays, that the activities of BMP-9 and BMP-9.pro-region complex were equivalent. Activin receptor-like kinase 1 (ALK-1), an orphan receptor in the TGF-beta family, was also identified as a potential receptor for BMP-9 based on surface plasmon resonance studies (BIAcore) and the ability of soluble ALK-1 to block the activity of BMP-9.pro-region complex in cell-based assays."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m503328200"xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m503328200"xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Brown M.A."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Brown M.A."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Singh M."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Singh M."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Choe S."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Choe S."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Baker K.A."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Baker K.A."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Sanyal I."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Sanyal I."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Naik C."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Naik C."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Tsareva T."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Tsareva T."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Mahoney A."xsd:string |
| http://purl.uniprot.org/citations/15851468 | http://purl.uniprot.org/core/author | "Mahoney A."xsd:string |