| http://purl.uniprot.org/citations/15856458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15856458 | http://www.w3.org/2000/01/rdf-schema#comment | "Tyrosinase-related protein-2 (TRP-2) is a known target antigen of spontaneous cytotoxic T cell responses in melanoma patients. Its frequent expression in metastatic tumors suggests that it might be an ideal candidate antigen for T cell-based immunotherapy. To provide knowledge about TRP-2-derived T cell epitopes useful for immunotherapy we applied a "reverse immunology strategy" based on repeated in vitro peptide stimulation of peripheral blood lymphocytes (PBL) from normal donors with predicted HLA-A*01 ligands. This led to the identification of TRP-2(181-190) as the first HLA-A*01-presented TRP-2-derived epitope. T-cell lines specific for peptide TRP-2(181-190) could be established from PBL of 50% of the normal HLA-A*01(+) donors tested. Such T cells responded specifically to autologous dendritic cells transduced virally with TRP-2, as well as to HLA-A*01(+), TRP-2(+) melanoma cells, although tumor cells had to be pretreated with IFN-gamma to become susceptible to T cell recognition. Interestingly, short-term in vitro peptide stimulation of PBL from HLA-A*01(+) melanoma patients showed the presence of TRP-2(181-190)-reactive CD8(+) T cells in some donors, suggesting their in vivo sensitization. Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.21132"xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Stevanovic S."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Song M."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Drexler I."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Sutter G."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Schadendorf D."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Jing W."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Paschen A."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Klemm M."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Muller-Berghaus J."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Nguyen X.D."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/author | "Osen W."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/pages | "944-948"xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/title | "Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2."xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/15856458 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15856458 |
| http://purl.uniprot.org/citations/15856458 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15856458 |
| http://purl.uniprot.org/uniprot/#_A8KAQ0-mappedCitation-15856458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15856458 |
| http://purl.uniprot.org/uniprot/#_P40126-mappedCitation-15856458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15856458 |
| http://purl.uniprot.org/uniprot/#_O75767-mappedCitation-15856458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15856458 |
| http://purl.uniprot.org/uniprot/#_Q0PK43-mappedCitation-15856458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15856458 |