| http://purl.uniprot.org/citations/1585646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1585646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1585646 | http://www.w3.org/2000/01/rdf-schema#comment | "We have examined the functional significance of the cysteine- and histidine-rich region (amino acids 22-53) of HTLV-I Tax. A modeling of this region suggests two possible overlapping zinc-finger-like motifs. Using a zinc blotting technique, we show that Tax binds zinc. An N-terminal deletion in Tax that removed this zinc-finger region abolished the ability to bind zinc. Site-directed mutagenesis was used to generate 10 separate mutations so as to discriminate between the two alternative zinc-binding structures. Each Tax mutant was studied for its ability to trans-activate the HTLV-I LTR. Five of the ten mutations inactivated trans-activation. Our results support that one of the two putative zinc fingers is an integral element of Tax structure."xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.org/dc/terms/identifier | "doi:10.1016/0042-6822(92)90530-3"xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.org/dc/terms/identifier | "doi:10.1016/0042-6822(92)90530-3"xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/author | "Jeang K.T."xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/author | "Jeang K.T."xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/author | "Semmes O.J."xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/author | "Semmes O.J."xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/pages | "754-764"xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/pages | "754-764"xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/title | "HTLV-I Tax is a zinc-binding protein: role of zinc in Tax structure and function."xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/title | "HTLV-I Tax is a zinc-binding protein: role of zinc in Tax structure and function."xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/1585646 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1585646 |
| http://purl.uniprot.org/citations/1585646 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1585646 |
| http://purl.uniprot.org/citations/1585646 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1585646 |
| http://purl.uniprot.org/citations/1585646 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1585646 |
| http://purl.uniprot.org/uniprot/P03409 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1585646 |
| http://purl.uniprot.org/uniprot/#_P03409-citation-1585646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1585646 |