| http://purl.uniprot.org/citations/15858013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15858013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15858013 | http://www.w3.org/2000/01/rdf-schema#comment | "While many clinical hepatitis C virus (HCV) infections are resistant to alpha interferon (IFN-alpha) therapy, subgenomic in vitro self-replicating HCV RNAs (HCV replicons) are characterized by marked IFN-alpha sensitivity. IFN-alpha treatment of replicon-containing cells results in a rapid loss of viral RNA via translation inhibition through double-stranded RNA-activated protein kinase (PKR) and also through a new pathway involving RNA editing by an adenosine deaminase that acts on double-stranded RNA (ADAR1). More than 200 genes are induced by IFN-alpha, and yet only a few are attributed with an antiviral role. We show that inhibition of both PKR and ADAR1 by the addition of adenovirus-associated RNA stimulates replicon expression and reduces the amount of inosine recovered from RNA in replicon cells. Small inhibitory RNA, specific for ADAR1, stimulated the replicon 40-fold, indicating that ADAR1 has a role in limiting replication of the viral RNA. This is the first report of ADAR's involvement in a potent antiviral pathway and its action to specifically eliminate HCV RNA through adenosine to inosine editing. These results may explain successful HCV replicon clearance by IFN-alpha in vitro and may provide a promising new therapeutic strategy for HCV as well as other viral infections."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.10.6291-6298.2005"xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.10.6291-6298.2005"xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Feinstone S.M."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Feinstone S.M."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Mihalik K."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Mihalik K."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Taylor D.R."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Taylor D.R."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Darnell M.E."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Darnell M.E."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Puig M."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/author | "Puig M."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/pages | "6291-6298"xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/pages | "6291-6298"xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/title | "New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/title | "New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1."xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/15858013 | http://purl.uniprot.org/core/volume | "79"xsd:string |