| http://purl.uniprot.org/citations/15858417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15858417 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the role of individual protein kinase C (PKC) isoforms during kainate toxicity in cortical neurons. Treatment with 50 microM kainate induced isoform-specific activation of PKC-delta according to the translocation from the soluble to the particulate fraction, while it caused remarkable decreases in PKC alpha, beta, epsilon and zeta in both fractions. Kainate-induced neuronal death was significantly increased by pharmacological inhibition of PKC-delta with rottlerin, suggesting a protective role of PKC-delta against kainate toxicity. A PKC activator phorbol 12-myristate 13-acetate remarkably attenuated the kainate-induced neuronal death. Although phorbol 12-myristate 13-acetate activates PKC-epsilon and PKC-delta, the protective effect of phorbol 12-myristate 13-acetate was almost completely abolished by rottlerin, but not by epsilonV1-2. These results suggest that activation of PKC-delta attenuates the kainate-induced cell death of cortical neurons."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.org/dc/terms/identifier | "doi:10.1097/00001756-200505120-00017"xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/author | "Park H.S."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/author | "Lee B.K."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/author | "Kim S.U."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/author | "Jung Y.S."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/author | "Shim J.K."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/author | "Moon C.H."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/author | "Baik E.J."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/name | "Neuroreport"xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/pages | "741-744"xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/title | "Activation of protein kinase C-delta attenuates kainate-induced cell death of cortical neurons."xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/15858417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15858417 |
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