| http://purl.uniprot.org/citations/15858601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15858601 | http://www.w3.org/2000/01/rdf-schema#comment | "Subtypes of HLA-DR4 are associated with susceptibility or protection against type 1 diabetes (T1DM). We addressed whether this reflects linkage disequilibrium with the true susceptibility locus by studying broader MHC haplotypes marked by alleles of HLA-B, IKBL (adjacent to TNFA) and complement C4. The study used a largely Caucasian cohort from Western Australia. HLA-DRB1*0401 and HLA-DRB1*0405 marked susceptibility to T1DM. In Caucasians, DRB1*0401 occurs predominantly in the 44.1 ancestral haplotype (AH; HLA-A2,B44, DRB1*0401,DQB1*0301) and the 62.1AH (HLA-A2,B15(62),DRB1*0401,DQB1*0302). HLA-B15 marked susceptibility and HLA-B44 marked with resistance to T1DM in patients and controls preselected for HLA-DRB1*0401. A gene between TNFA and HLA-B on the 8.1AH (HLA-A1,B8,;DR3,DQ2) modifies the effects of the class II alleles. Here, alleles characteristic of the 62.1AH (C4B3, IKBL+446*T and HLA-A2,B15) were screened in donors preselected for HLA-DRB1*0401. C4B3 was associated with diabetes, consistent with a diabetes gene telomeric of MHC class II. However, increases in carriage of IKBL+446*T and HLA-A2,B15 were marginal, as too few control subjects were available with the diabetogenic alleles. However, with these tools, selection of HLA-DRB1*0401, DQB1*0302 donors who are positive and negative for C4B3 will allow bidirectional mapping of diabetes genes in the central MHC."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.gene.6364210"xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Scott A."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Gut I."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Davis E."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Allcock R."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Puschendorf M."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Sayer D."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Witt C."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Price P."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Christiansen F."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "McCann V."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Kucharzak R."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/author | "Windsor L."xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/pages | "298-304"xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/title | "Does a central MHC gene in linkage disequilibrium with HLA-DRB1*0401 affect susceptibility to type 1 diabetes?"xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/15858601 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15858601 |
| http://purl.uniprot.org/citations/15858601 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15858601 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15858601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15858601 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15858601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15858601 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-15858601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15858601 |