| http://purl.uniprot.org/citations/15860226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15860226 | http://www.w3.org/2000/01/rdf-schema#comment | "Somatic hypermutation (SHM) occurs in the variable region of immunoglobulin genes in germinal center B cells where it plays an important role in affinity maturation of the T cell-dependent immune response. Although the precise mechanism of SHM is still unknown, it has been suggested that error-prone DNA polymerases (Pol) are involved in SHM. Poliota is a member of the error-prone Y-family of DNA polymerases which exhibit translesion synthesis activity in vitro and are highly mutagenic when replicating on non-damaged DNA templates. In BL2 cell line stimulated to induce SHM, the induction is Poliota-dependent. However, in 129-derived strains of mice deficient in Poliota, SHM is normal. One possible explanation for this discrepancy is that a Poliota deficiency in mice might be compensated for by another error-prone DNA polymerase, such as Polkappa, which also belongs to the Y-family of DNA polymerases. Although SHM in Polkappa-deficient mice is normal, their deficiency might be compensated for by Poliota. In this study, we generated Polkappa-Poliota double-deficient mice and examined them for SHM. We found that the double-deficient mice had the normal SHM frequency and profile, rendering them indistinguishable from Polkappa-deficient mice and thus conclude that Poliota and Polkappa are dispensable for SHM in mice."xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imlet.2004.11.022"xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/author | "Ohmori H."xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/author | "Shimizu T."xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/author | "Yamada S."xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/author | "Ishiguro M."xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/author | "Azuma T."xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/author | "Kanjo N."xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/name | "Immunol Lett"xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/pages | "259-264"xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/title | "Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/15860226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15860226 |
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