| http://purl.uniprot.org/citations/15861132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15861132 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanisms governing early cardiogenesis are still largely unknown. Interestingly, the retinoblastoma protein (Rb), a regulator of cell cycle, has recently emerged as a new candidate regulating cell differentiation. Rb-/-mice die at midgestation and mice lacking E2f1/E2f3, downstream components of the Rb-dependent transcriptional pathway, die of heart failure. To gain insight into the function of Rb pathway in early cardiogenesis, we used Rb-/-embryonic stem (ES) cells differentiating into cardiomyocytes. Rb-/-cells displayed a dramatic delay in expression of cardiac-specific transcription factors and in turn in the whole process of cardiac differentiation. The phenotype of Rb-/-ES cell-derived cardiomyocytes was rescued by reintroducing Rb in cardiac progenitors, by stimulating the BMP-dependent cardiogenic pathway or by overexpression of Nkx2.5. ES cells deficient in the recently identified factor LEK1, a murine homolog of the cardiomyogenic factor 1, or specific disruption of Rb-LEK1 interaction into the nucleus of differentiating ES cells recapitulated the delay in cardiac differentiation of Rb-/-ES cells. Thus, we provide evidence for a novel Rb/LEK1-dependent and BMP-independent transcriptional program, which plays a pivotal role in priming ES cells toward a cardiac fate."xsd:string |
| http://purl.uniprot.org/citations/15861132 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600652"xsd:string |
| http://purl.uniprot.org/citations/15861132 | http://purl.uniprot.org/core/author | "Grey C."xsd:string |
| http://purl.uniprot.org/citations/15861132 | http://purl.uniprot.org/core/author | "Puceat M."xsd:string |
| http://purl.uniprot.org/citations/15861132 | http://purl.uniprot.org/core/author | "Menard C."xsd:string |
| http://purl.uniprot.org/citations/15861132 | http://purl.uniprot.org/core/author | "Papadimou E."xsd:string |
| http://purl.uniprot.org/citations/15861132 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15861132 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/15861132 | http://purl.uniprot.org/core/pages | "1750-1761"xsd:string |
| http://purl.uniprot.org/citations/15861132 | http://purl.uniprot.org/core/title | "Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage."xsd:string |
| http://purl.uniprot.org/citations/15861132 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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