| http://purl.uniprot.org/citations/15861137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15861137 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial cadherin (VE-cadherin) mediates contact inhibition of cell growth in quiescent endothelial cell layers. Searching for proteins that could be involved in VE-cadherin signaling, we found the cytosolic C-terminal Src kinase (Csk), a negative regulator of Src family kinases. We show that Csk binds via its SH2 domain to the phosphorylated tyrosine 685 of VE-cadherin. VE-cadherin recruits Csk to cell contacts and both proteins can be co-precipitated from cell lysates of transfected cells and endothelial cells. Association of VE-cadherin and Csk in endothelial cells increased with increasing cell density. CHO cells expressing the tyrosine replacement mutant VE-cadherin-Y685F grow to higher cell densities than cells expressing wild-type VE-cadherin. Overexpression of Csk in these cells under an inducible promoter inhibits cell proliferation in the presence and absence of VE-cadherin, but not in the presence of VE-cadherin-Y685F. Reduction of Csk expression by RNA interference enhances endothelial cell proliferation. Our results suggest that the phosphorylated tyrosine residue 685 of VE-cadherin and probably the binding of Csk to this site are involved in inhibition of cell growth triggered by cell density."xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600647"xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/author | "Ebnet K."xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/author | "Koch S."xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/author | "Vestweber D."xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/author | "Funke R."xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/author | "Baumeister U."xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/author | "Vorschmitt H."xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/pages | "1686-1695"xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/title | "Association of Csk to VE-cadherin and inhibition of cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15861137 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15861137 |
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