| http://purl.uniprot.org/citations/15864310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15864310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15864310 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases. Here we used ASK1-deficient mice to show that ASK1 was selectively required for lipopolysaccharide-induced activation of p38 but not of Jnk or the transcription factor NF-kappaB. ASK1 was required for the induction of proinflammatory cytokines dependent on Toll-like receptor 4 (TLR4) but not TLR2 or other TLRs. Consistent with this, ASK1-deficient mice were resistant to lipopolysaccharide-induced septic shock. Lipopolysaccharide induced the production of intracellular reactive oxygen species, which was required for the formation of a complex of the adaptor molecule TRAF6 and ASK1 and subsequent activation of the ASK1-p38 pathway. Our data demonstrate that the reactive oxygen species-dependent TRAF6-ASK1-p38 axis is crucial for TLR4-mediated mammalian innate immunity."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1200"xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1200"xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Nagai S."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Nagai S."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Matsuzawa A."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Matsuzawa A."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Noguchi T."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Noguchi T."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Ichijo H."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Ichijo H."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Nishitoh H."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Nishitoh H."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Koyasu S."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Koyasu S."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Sadamitsu C."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Sadamitsu C."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Saegusa K."xsd:string |
| http://purl.uniprot.org/citations/15864310 | http://purl.uniprot.org/core/author | "Saegusa K."xsd:string |