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http://purl.uniprot.org/citations/15867178http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15867178http://www.w3.org/2000/01/rdf-schema#comment"

Background

Abnormally elevated blood pressure is the most prevalent risk factor for cardiovascular disease. The large-conductance, voltage- and Ca2+-dependent K+ (BK) channel has been proposed as an important effector in the control of vascular tone by linking membrane depolarization and local increases in cytosolic Ca2+ to hyperpolarizing K+ outward currents. However, the BK channel may also affect blood pressure by regulating salt and fluid homeostasis, particularly by adjusting the renin-angiotensin-aldosterone system.

Methods and results

Here we report that deletion of the pore-forming BK channel alpha subunit leads to a significant blood pressure elevation resulting from hyperaldosteronism accompanied by decreased serum K+ levels as well as increased vascular tone in small arteries. In smooth muscle from small arteries, deletion of the BK channel leads to a depolarized membrane potential, a complete lack of membrane hyperpolarizing spontaneous K+ outward currents, and an attenuated cGMP vasorelaxation associated with a reduced suppression of Ca2+ transients by cGMP. The high level of BK channel expression observed in wild-type adrenal glomerulosa cells, together with unaltered serum renin activities and corticotropin levels in mutant mice, suggests that the hyperaldosteronism results from abnormal adrenal cortical function in BK(-/-) mice.

Conclusions

These results identify previously unknown roles of BK channels in blood pressure regulation and raise the possibility that BK channel dysfunction may underlie specific forms of hyperaldosteronism."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.org/dc/terms/identifier"doi:10.1161/01.cir.0000156448.74296.fe"xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Zhao H."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Feil R."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Hofmann F."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Schubert R."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Kenyon C."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Arntz C."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Feil S."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Ruth P."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Knaus H.G."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Korth M."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Sailer C.A."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Storm J.F."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Kamm S."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Sausbier U."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Shipston M.J."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Sausbier M."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Abdullah U."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Zhou X.B."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Gollasch M."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Krippeit-Drews P."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Neuhuber W."xsd:string
http://purl.uniprot.org/citations/15867178http://purl.uniprot.org/core/author"Bucurenciu I."xsd:string
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