| http://purl.uniprot.org/citations/15868410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15868410 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study we analyzed the proteolytic activity of MMP-19 and its impact on keratinocyte migration. In the HaCaT keratinocyte cell line overexpressing wild-type MMP-19 (HaCaT-WT), transmigration through fibrin and type IV collagen matrices was significantly increased compared to cells harboring a catalytically inactive mutant (HaCaT-EA). Studying the expression of MMP-19 in early stages of squamous cell cancer (SCC), we found co-localization of MMP-19 and laminin 5 at the invading tumor front but not in suprabasal epidermis of the tumor. Examination of laminin 5 processing revealed increased processing of the gamma2 chain in the medium and matrix of HaCaT-WT cells and degradation by recombinant human MMP-19 to 105-kDa and 80-kDa fragments. Parental HaCaT grown on the matrix of HaCaT-WT and HaCaT-EA cells displayed differential tyrosine phosphorylation. Using integrin blocking and stimulating antibodies we could attribute these differences to a shift from beta4-integrin-dependent signaling on the HaCaT-EA matrix toward alpha3-integrin-dependent signaling on the HaCaT-WT matrix. As a consequence, parental HaCaT showed increased migration on the matrix of HaCaT-WT cells. These data suggest that the MMP-19-dependent processing of the gamma2 chains leads to the integrin switch favoring epithelial migration and that MMP-19 actively participates in the early stages of SCC invasion."xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-005-4478-8"xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/author | "Titz B."xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/author | "Sedlacek R."xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/author | "Ludwig A."xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/author | "Proksch E."xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/author | "Sadowski T."xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/author | "Dietrich S."xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/author | "Koschinsky F."xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/pages | "870-880"xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/title | "Matrix metalloproteinase 19 processes the laminin 5 gamma 2 chain and induces epithelial cell migration."xsd:string |
| http://purl.uniprot.org/citations/15868410 | http://purl.uniprot.org/core/volume | "62"xsd:string |
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