| http://purl.uniprot.org/citations/15870108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15870108 | http://www.w3.org/2000/01/rdf-schema#comment | "tGolgin-1 (trans-Golgi p230, golgin-245) is a member of a family of large peripheral membrane proteins that associate with the trans-Golgi network (TGN) via a C-terminal GRIP domain. Some GRIP-domain proteins have been implicated in endosome-to-TGN transport but no function for tGolgin-1 has been described. Here, we show that tGolgin-1 production is required for efficient retrograde distribution of Shiga toxin from endosomes to the Golgi. Surprisingly, we also found an indirect requirement for tGolgin-1 in Golgi positioning. In HeLa cells depleted of tGolgin-1, the normally centralized Golgi and TGN membranes were displaced to the periphery, forming 'mini stacks'. These stacks resembled those in cells with disrupted microtubules or dynein-dynactin motor, in that they localized to endoplasmic-reticulum exit sites, maintained their secretory capacity and cis-trans polarity, and were relatively immobile by video microscopy. The mini stacks formed concomitant with a failure of pre-Golgi elements to migrate along microtubules towards the microtubule-organizing centre. The requirement for tGolgin-1 in Golgi positioning did not appear to reflect direct binding of tGolgin-1 to motile pre-Golgi membranes, because distinct Golgi and tGolgin-1-containing TGN elements that formed after recovery of HeLa cells from brefeldin-A treatment moved independently toward the microtubule-organizing centre. These data demonstrate that tGolgin-1 functions in Golgi positioning indirectly, probably by regulating retrograde movement of cargo required for recruitment or activation of dynein-dynactin complexes on newly formed Golgi elements."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02358"xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Koval M."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "McCaffery J.M."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Burd C.G."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Marks M.S."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Setty S.R."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Yoshino A."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Holzbaur E.L."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Johannes L."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Whiteman E.L."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Poynton C."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/author | "Saint-Pol A."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/pages | "2279-2293"xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/title | "tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre."xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/15870108 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15870108 |
| http://purl.uniprot.org/citations/15870108 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15870108 |
| http://purl.uniprot.org/uniprot/#_A0A076NA11-mappedCitation-15870108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15870108 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TPI8-mappedCitation-15870108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15870108 |
| http://purl.uniprot.org/uniprot/#_A0A9L9PX25-mappedCitation-15870108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15870108 |
| http://purl.uniprot.org/uniprot/#_A8K3D5-mappedCitation-15870108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15870108 |