| http://purl.uniprot.org/citations/15870271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15870271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15870271 | http://www.w3.org/2000/01/rdf-schema#comment | "CENP-A is an evolutionarily conserved, centromere-specific variant of histone H3 that is thought to play a central role in directing kinetochore assembly and in centromere function. Here, we have analyzed the consequences of disrupting the CENP-A gene in the chicken DT40 cell line. In CENP-A-depleted cells, kinetochore protein assembly is impaired, as indicated by mislocalization of the inner kinetochore proteins CENP-I, CENP-H, and CENP-C as well as the outer components Nuf2/Hec1, Mad2, and CENP-E. However, BubR1 and the inner centromere protein INCENP are efficiently recruited to kinetochores. Following CENP-A depletion, chromosomes are deficient in proper congression on the mitotic spindle and there is a transient delay in prometaphase. CENP-A-depleted cells further proceed through anaphase and cytokinesis with unequal chromosome segregation, suggesting that some kinetochore function remains following substantial depletion of CENP-A. We furthermore demonstrate that CENP-A-depleted cells exhibit a specific defect in maintaining kinetochore localization of the checkpoint protein BubR1 under conditions of checkpoint activation. Our data thus point to a specific role for CENP-A in assembly of kinetochores competent in the maintenance of mitotic checkpoint signaling."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.10.3967-3981.2005"xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.10.3967-3981.2005"xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Brown W."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Brown W."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Fukagawa T."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Fukagawa T."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Vagnarelli P."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Vagnarelli P."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Trouche D."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Trouche D."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Earnshaw W."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Earnshaw W."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Burns E."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Burns E."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Regnier V."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Regnier V."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Zerjal T."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/author | "Zerjal T."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/15870271 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |