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http://purl.uniprot.org/citations/15870279http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15870279http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15870279http://www.w3.org/2000/01/rdf-schema#comment"In contrast to previous steady-state analyses of the O(2)-responsive transcriptome, here we examined the dynamics of the response to short-term anaerobiosis (2 generations) in both catabolite-repressed (glucose) and derepressed (galactose) cells, assessed the specific role that Msn2 and Msn4 play in mediating the response, and identified gene networks using a novel clustering approach. Upon shifting cells to anaerobic conditions in galactose medium, there was an acute ( approximately 10 min) yet transient (<45 min) induction of Msn2-and/or Msn4-regulated genes associated with the remodeling of reserve energy and catabolic pathways during the switch from mixed respiro-fermentative to strictly fermentative growth. Concomitantly, MCB- and SCB-regulated networks associated with the G(1)/S transition of the cell cycle were transiently down-regulated along with rRNA processing genes containing PAC and RRPE motifs. Remarkably, none of these gene networks were differentially expressed when cells were shifted in glucose, suggesting that a metabolically derived signal arising from the abrupt cessation of respiration, rather than O(2) deprivation per se, elicits this "stress response." By approximately 0.2 generation of anaerobiosis in both media, more chronic, heme-dependent effects were observed, including the down-regulation of Hap1-regulated networks, derepression of Rox1-regulated networks, and activation of Upc2-regulated ones. Changes in these networks result in the functional remodeling of the cell wall, sterol and sphingolipid metabolism, and dissimilatory pathways required for long-term anaerobiosis. Overall, this study reveals that the acute withdrawal of oxygen can invoke a metabolic state-dependent "stress response" but that acclimatization to oxygen deprivation is a relatively slow process involving complex changes primarily in heme-regulated gene networks."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.org/dc/terms/identifier"doi:10.1128/mcb.25.10.4075-4091.2005"xsd:string
http://purl.uniprot.org/citations/15870279http://purl.org/dc/terms/identifier"doi:10.1128/mcb.25.10.4075-4091.2005"xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/author"Burke P.V."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/author"Burke P.V."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/author"Lai L.C."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/author"Lai L.C."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/author"Kwast K.E."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/author"Kwast K.E."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/author"Kosorukoff A.L."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/author"Kosorukoff A.L."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/name"Mol. Cell. Biol."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/name"Mol. Cell. Biol."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/pages"4075-4091"xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/pages"4075-4091"xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/title"Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/title"Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media."xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/15870279http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/15870279http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15870279
http://purl.uniprot.org/citations/15870279http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15870279
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