| http://purl.uniprot.org/citations/15870285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15870285 | http://www.w3.org/2000/01/rdf-schema#comment | "The expression of the glutathione S-transferase gene (GST), whose induction accounts for cancer chemoprevention, is regulated by activation of CCAAT/enhancer binding protein beta (C/EBPbeta) and NF-E2-related factor 2 (Nrf2). The present study investigated the repressing effects of activating glucocorticoid receptor (GR) on C/EBPbeta- and Nrf2-mediated GSTA2 gene induction and the mechanism. Dexamethasone that activates GR inhibited constitutive and oltipraz- or tert-butylhydroquinone (t-BHQ)-inducible GSTA2 expression in H4IIE cells. Also, dexamethasone repressed GSTA2 promoter-luciferase gene activity. Dexamethasone-GR activation did not inhibit nuclear translocation of C/EBPbeta or Nrf2 nor their DNA binding activities induced by oltipraz or t-BHQ. Deletion of the glucocorticoid response element (GRE) in the GSTA2 promoter abolished dexamethasone inhibition of the gene induction. Immunoprecipitation-immunoblotting, chromatin immunoprecipitation, and GST pull-down assays revealed that silencing mediator for retinoid and thyroid hormone receptors (SMRT), a corepressor recruited to steroid-GR complex for histone deacetylation, bound to TAD domain of C/EBPbeta and Neh4/5 domain of Nrf2. The GSTA2 promoter-luciferase activities were decreased by SMRT but not by truncated SMRTs. The small interference RNA (siRNA) against SMRT abolished SMRT repression of the gene induction by C/EBPbeta or Nrf2. The plasmid transfection and siRNA experiments directly evidenced the functional role of SMRT in GSTA2 repression. In conclusion, dexamethasone antagonizes C/EBPbeta- and Nrf2-mediated GSTA2 gene induction via ligand-GR binding to the GRE, and steroid-mediated GSTA2 repression involves inactivation of C/EBPbeta and Nrf2 by SMRT recruited to steroid-GR complex."xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.10.4150-4165.2005"xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://purl.uniprot.org/core/author | "Choi D.W."xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://purl.uniprot.org/core/author | "Kim S.G."xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://purl.uniprot.org/core/author | "Cho I.J."xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://purl.uniprot.org/core/author | "Ki S.H."xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15870285 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://purl.uniprot.org/core/pages | "4150-4165"xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://purl.uniprot.org/core/title | "Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression."xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/15870285 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15870285 |
| http://purl.uniprot.org/citations/15870285 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15870285 |
| http://purl.uniprot.org/uniprot/P28033#attribution-17511F872EA50B3737717E33FCABFAEC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/P06537#attribution-17511F872EA50B3737717E33FCABFAEC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/Q9WUB5#attribution-1EFD7FA41B5825F37EAA0164019D8188 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/Q60795#attribution-17511F872EA50B3737717E33FCABFAEC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/D3ZXN9#attribution-1EFD7FA41B5825F37EAA0164019D8188 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/D3ZXN9#attribution-802B6BFEDAC0263E4274929BE1799842 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/A6J0X3#attribution-1EFD7FA41B5825F37EAA0164019D8188 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/A6J0X3#attribution-802B6BFEDAC0263E4274929BE1799842 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/A0A0G2JU91#attribution-1EFD7FA41B5825F37EAA0164019D8188 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/A0A0G2JU91#attribution-802B6BFEDAC0263E4274929BE1799842 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |
| http://purl.uniprot.org/uniprot/A0A8I6AN60#attribution-1EFD7FA41B5825F37EAA0164019D8188 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15870285 |