| http://purl.uniprot.org/citations/15872086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15872086 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously demonstrated that phospholipase C (PLC)-gamma1 is required for calcium-induced human keratinocyte differentiation. In the present study, we investigated whether the activation of PLC-gamma1 by nonreceptor kinases such as src and fyn plays a role in mediating this process. Our results showed that the combination of dominant negative src and fyn blocked calcium-stimulated PLC-gamma1 activity and human keratinocyte differentiation, whereas each separately has little effect. However, unlike the activation of PLC-gamma1 by epidermal growth factor, calcium-induced activation of PLC-gamma1 was not a result of direct tyrosine phosphorylation. Therefore, we examined an alternative mechanism, in particular phosphatidylinositol 3,4,5-triphosphate (PIP3) formed as a product of phosphatidylinositol 3-kinase (PI3K) activity. PIP3 binds to and activates PLC-gamma1. The combination of dominant negative src and fyn blocked calcium-induced tyrosine phosphorylation of the regulatory subunit of PI3K, p85alpha, and the activity of the catalytic subunit of PI3K. PI3K inhibitors blocked calcium activation of PLC-gamma1 as well as the induction of keratinocyte differentiation markers involucrin and transglutaminase. These data indicate that calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K. This activation is required for calcium-induced human keratinocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/15872086 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-02-0109"xsd:string |
| http://purl.uniprot.org/citations/15872086 | http://purl.uniprot.org/core/author | "Xie Z."xsd:string |
| http://purl.uniprot.org/citations/15872086 | http://purl.uniprot.org/core/author | "Singleton P.A."xsd:string |
| http://purl.uniprot.org/citations/15872086 | http://purl.uniprot.org/core/author | "Bikle D.D."xsd:string |
| http://purl.uniprot.org/citations/15872086 | http://purl.uniprot.org/core/author | "Bourguignon L.Y."xsd:string |
| http://purl.uniprot.org/citations/15872086 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15872086 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/15872086 | http://purl.uniprot.org/core/pages | "3236-3246"xsd:string |
| http://purl.uniprot.org/citations/15872086 | http://purl.uniprot.org/core/title | "Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1."xsd:string |
| http://purl.uniprot.org/citations/15872086 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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