| http://purl.uniprot.org/citations/15879081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15879081 | http://www.w3.org/2000/01/rdf-schema#comment | "The elimination of activated T cells is important to maintain homeostasis and avoid immunopathology. CD95 (Fas/APO-1) has been identified as a death mediator for activated T cells in vitro but the function of CD95 in death of mature T cells in vivo is still controversial. Here we show that triggering of the costimulatory TNF receptor family member CD27 sensitized T cells for CD95-induced apoptosis. CD95-deficient (lpr/lpr) T cells massively expanded and differentiated into IFN-gamma-secreting effector cells in transgenic mice that constitutively express the CD27 ligand, CD70. Concomitantly, CD95-deficient CD70 transgenic mice became moribund by 4 wk of age with severe liver pathology and bone marrow failure. These findings establish that CD95 is a critical regulator of effector T cell homeostasis in chronic immune activation."xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.10.5915"xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/author | "van der Valk M."xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/author | "Baars P.A."xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/author | "Tesselaar K."xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/author | "van Lier R.A."xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/author | "Arens R."xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/author | "van Oers M.H."xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/author | "Jak M."xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/pages | "5915-5920"xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/title | "Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation."xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15879081 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15879081 |
| http://purl.uniprot.org/citations/15879081 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15879081 |
| http://purl.uniprot.org/uniprot/#_D3Z7W5-mappedCitation-15879081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879081 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-15879081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879081 |
| http://purl.uniprot.org/uniprot/#_A0A494BBE8-mappedCitation-15879081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879081 |
| http://purl.uniprot.org/uniprot/#_A0A494BBP5-mappedCitation-15879081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879081 |
| http://purl.uniprot.org/uniprot/#_A1Y9B2-mappedCitation-15879081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879081 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-15879081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879081 |
| http://purl.uniprot.org/uniprot/#_B7ZW87-mappedCitation-15879081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879081 |
| http://purl.uniprot.org/uniprot/#_C4NUL9-mappedCitation-15879081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879081 |