| http://purl.uniprot.org/citations/15879084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15879084 | http://www.w3.org/2000/01/rdf-schema#comment | "Ly108, a glycoprotein of the signaling lymphocytic activation molecule family of cell surface receptors expressed by T, B, NK, and APCs has been shown to have a role in NK cell cytotoxicity and T cell cytokine responses. In this study, we describe that CD4(+) T cells from mice with a targeted disruption of exons 2 and 3 of Ly108 (Ly108(DeltaE2+3)) produce significantly less IL-4 than wild-type CD4(+) cells, as judged by in vitro assays and by in vivo responses to cutaneous infection with Leishmania mexicana. Surprisingly, neutrophil functions are controlled by Ly108. Ly108(DeltaE2+3) mice are highly susceptible to infection with Salmonella typhimurium, bactericidal activity of Ly108(DeltaE2+3) neutrophils is defective, and their production of IL-6, IL-12, and TNF-alpha is increased. The aberrant bactericidal activity by Ly108(DeltaE2+3) neutrophils is a consequence of severely reduced production of reactive oxygen species following phagocytosis of bacteria. Thus, Ly108 serves as a regulator of both innate and adaptive immune responses."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.10.5931"xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Fraser C."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Coyle A.J."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Morra M."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Rietdijk S."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Howie D."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Satoskar A.R."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Faubion W.A."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Julien A."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Laroux F.S."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/author | "Rosas L.E."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/pages | "5931-5935"xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/title | "Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions."xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15879084 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15879084 |
| http://purl.uniprot.org/citations/15879084 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15879084 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY21-mappedCitation-15879084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879084 |
| http://purl.uniprot.org/uniprot/#_Q18PG5-mappedCitation-15879084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879084 |
| http://purl.uniprot.org/uniprot/#_Q18PJ0-mappedCitation-15879084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879084 |
| http://purl.uniprot.org/uniprot/#_Q18PJ2-mappedCitation-15879084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879084 |