| http://purl.uniprot.org/citations/15879134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15879134 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have shown that the in vitro ligation of FcgammaRs with IgG-opsonized Leishmania amastigotes promotes IL-10 production by macrophages. In addition, infection of either BALB/c mice lacking the common gamma-chain of Fc receptors (FcgammaR(-/-)) or mice genetically altered to lack circulating Ab (J(H)D) with Leishmania pifanoi results in reduced and delayed lesion development and a deficit in the recruitment of inflammatory cells into infected lesions. We show in this study that FcgammaR(-/-) mice can control infection with Leishmania major and totally resolve cutaneous lesions. The ability to eventually control infection is not associated with a reduction in lesion inflammation or a reduction in the ability of Leishmania to parasitize cells through week 6 of infection. The immune response in healing FcgammaR(-/-) mice is associated with a reduction in numbers of cells producing Th2-type cytokines, including IL-4 and IL-10, but not an increase in numbers of IFN-gamma-producing cells characteristic of a dominant Th1-type response. Instead, we observe a reduction in levels of IL-10 and TGF-beta within infected lesions, including reduced levels of these cytokines within parasitized macrophages. Together, these results suggest that uptake of opsonized parasites via FcgammaRs may be a strong in vivo stimulus for the production of anti-inflammatory cytokines that play a role in susceptibility to infection."xsd:string |
| http://purl.uniprot.org/citations/15879134 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.10.6340"xsd:string |
| http://purl.uniprot.org/citations/15879134 | http://purl.uniprot.org/core/author | "Farrell J.P."xsd:string |
| http://purl.uniprot.org/citations/15879134 | http://purl.uniprot.org/core/author | "Padigel U.M."xsd:string |
| http://purl.uniprot.org/citations/15879134 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15879134 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15879134 | http://purl.uniprot.org/core/pages | "6340-6345"xsd:string |
| http://purl.uniprot.org/citations/15879134 | http://purl.uniprot.org/core/title | "Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells."xsd:string |
| http://purl.uniprot.org/citations/15879134 | http://purl.uniprot.org/core/volume | "174"xsd:string |
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