| http://purl.uniprot.org/citations/15879141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15879141 | http://www.w3.org/2000/01/rdf-schema#comment | "In acute inflammation, infiltration of neutrophils often precedes a second phase of monocyte invasion, and data in the literature suggest that neutrophils may directly stimulate mobilization of monocytes via neutrophil granule proteins. In this study, we present a role for neutrophil-derived heparin-binding protein (HBP) in monocyte arrest on endothelium. Adhesion of neutrophils to bovine aorta endothelial cells (ECs) or HUVEC-triggered secretion of HBP and binding of the protein to the EC surface. Blockade of neutrophil adhesion by treatment with a mAb to CD18 greatly reduced accumulation of HBP. In a flow chamber model, immobilized recombinant HBP induced arrest of human monocytes or monocytic Mono Mac 6 (MM6) cells to activated EC or plates coated with recombinant adhesion molecules (E-selectin, P-selectin, VCAM-1). However, immobilized recombinant HBP did not influence arrest of neutrophils or lymphocytes. Treatment of MM6 cells with recombinant HBP evoked a rapid and clear-cut increase in cytosolic free Ca(2+) that was found to be critical for the HBP-induced monocyte arrest inasmuch as pretreatment with the intracellular calcium chelating agent BAPTA-AM abolished the evoked increase in adhesion. Thus, secretion of a neutrophil granule protein, accumulating on the EC surface and promoting arrest of monocytes, could contribute to the recruitment of monocytes at inflammatory loci."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.10.6399"xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/author | "Flodgaard H."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/author | "Lindbom L."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/author | "Soehnlein O."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/author | "Eriksson E.E."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/author | "Kenne E."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/author | "Rotzius P."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/author | "Ulbrich H."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/pages | "6399-6405"xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/title | "Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions."xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15879141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15879141 |
| http://purl.uniprot.org/citations/15879141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15879141 |
| http://purl.uniprot.org/uniprot/P20160#attribution-0EFDA9CD6E5E28C4EFE9EC3FFF1D777C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15879141 |
| http://purl.uniprot.org/uniprot/P20160#attribution-5B9B6538724BA620F66991A5967E10F8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15879141 |
| http://purl.uniprot.org/uniprot/P16109#attribution-5B9B6538724BA620F66991A5967E10F8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15879141 |
| http://purl.uniprot.org/uniprot/P19320#attribution-5B9B6538724BA620F66991A5967E10F8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15879141 |
| http://purl.uniprot.org/uniprot/#_P20160-mappedCitation-15879141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879141 |
| http://purl.uniprot.org/uniprot/#_Q86SR2-mappedCitation-15879141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15879141 |
| http://purl.uniprot.org/uniprot/P20160 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15879141 |