http://purl.uniprot.org/citations/15880112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15880112 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanisms that direct the migration of early T lymphocyte progenitors to the thymus are unknown. We show here that P-selectin is expressed by thymic endothelium and that lymphoid progenitors in bone marrow and thymus bind P-selectin. Parabiosis, competitive thymus reconstitution and short-term homing assays indicated that P-selectin and its ligand PSGL-1 are functionally important components of the thymic homing process. Accordingly, thymi of mice lacking PSGL-1 contained fewer early thymic progenitors and had increased empty niches for prothymocytes compared with wild-type mice. Furthermore, the number of resident thymic progenitors controls thymic expression of P-selectin, suggesting that regulation of P-selectin expression by a thymic 'niche occupancy sensor' may be used to direct progenitor access."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1203"xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/author | "Yi L."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/author | "Ziltener H.J."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/author | "Carlow D.A."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/author | "Corbel S.Y."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/author | "So L."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/author | "Rossi F.M."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/author | "Merzaban J.S."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/author | "Duenas J."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/author | "Gossens K."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/pages | "626-634"xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/title | "Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1."xsd:string |
http://purl.uniprot.org/citations/15880112 | http://purl.uniprot.org/core/volume | "6"xsd:string |
http://purl.uniprot.org/citations/15880112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15880112 |
http://purl.uniprot.org/citations/15880112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15880112 |
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http://purl.uniprot.org/uniprot/#_A0A0J9YUH7-mappedCitation-15880112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15880112 |
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http://purl.uniprot.org/uniprot/#_A0A0G2JF74-mappedCitation-15880112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15880112 |
http://purl.uniprot.org/uniprot/#_F6TL88-mappedCitation-15880112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15880112 |
http://purl.uniprot.org/uniprot/#_Q62170-mappedCitation-15880112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15880112 |