| http://purl.uniprot.org/citations/15883195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15883195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15883195 | http://www.w3.org/2000/01/rdf-schema#comment | "14-3-3 proteins are phosphoserine/threonine-binding proteins that play important roles in many regulatory processes, including intracellular protein targeting. 14-3-3 proteins can anchor target proteins in the cytoplasm and in the nucleus or can mediate their nuclear export. So far, no role for 14-3-3 in mediating nuclear import has been described. There is also mounting evidence that nuclear import is regulated by the phosphorylation of cargo proteins, but the underlying mechanism remains elusive. Myopodin is a dual-compartment, actin-bundling protein that functions as a tumor suppressor in human bladder cancer. In muscle cells, myopodin redistributes between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. We show that importin alpha binding and the subsequent nuclear import of myopodin are regulated by the serine/threonine phosphorylation-dependent binding of myopodin to 14-3-3. These results establish a novel paradigm for the promotion of nuclear import by 14-3-3 binding. They provide a molecular explanation for the phosphorylation-dependent nuclear import of nuclear localization signal-containing cargo proteins."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200411169"xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200411169"xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Faul C."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Faul C."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Hachet V."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Hachet V."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Huettelmaier S."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Huettelmaier S."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Mundel P."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Mundel P."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Oh J."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Oh J."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Singer R.H."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/author | "Singer R.H."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/pages | "415-424"xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/pages | "415-424"xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/title | "Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3."xsd:string |
| http://purl.uniprot.org/citations/15883195 | http://purl.uniprot.org/core/title | "Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3."xsd:string |