| http://purl.uniprot.org/citations/15887239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15887239 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of cell cycle progression involves redox (oxidation-reduction)-dependent modification of proteins including the mitosis-inducing phosphatase Cdc25C. The role of vitamin C (ascorbic acid, ASC), a known modulator of the cellular redox status, in regulating mitotic entry was investigated in this study. We demonstrated that vitamin C inhibits DNA synthesis in HeLa cells and, mainly the form of dehydroascorbic acid (DHA), delays the entry of p53-deficient synchronized HeLa and T98G cancer cells into mitosis. High concentrations of Vitamin C caused transient S and G2 arrest in both cell lines by delaying the activation of the M-phase promoting factor (MPF), Cdc2/cyclin-B complex. Although vitamin C did not inhibit the accumulation of cyclin-B1, it may have increased the level of Cdc2 inhibitory phosphorylation. This was achieved by transiently maintaining Cdc25C, the activator of Cdc2, both in low levels and in a phosphorylated on Ser216 inactive form that binds to 14-3-3 proteins contributing thus to the nuclear exclusion of Cdc25C. As expected, vitamin C prevented the nuclear accumulation of Cdc25C in both cell lines. In conclusion, it seems that vitamin C induces transient cell cycle arrest, at least in part, by delaying the accumulation and the activation of Cdc25C."xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.20405"xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://purl.uniprot.org/core/author | "Thomas C.G."xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://purl.uniprot.org/core/author | "Evangelou A.M."xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://purl.uniprot.org/core/author | "Kalfakakou V.P."xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://purl.uniprot.org/core/author | "Vezyraki P.E."xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15887239 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://purl.uniprot.org/core/pages | "310-318"xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://purl.uniprot.org/core/title | "Vitamin C transiently arrests cancer cell cycle progression in S phase and G2/M boundary by modulating the kinetics of activation and the subcellular localization of Cdc25C phosphatase."xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://purl.uniprot.org/core/volume | "205"xsd:string |
| http://purl.uniprot.org/citations/15887239 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15887239 |
| http://purl.uniprot.org/citations/15887239 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15887239 |
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| http://purl.uniprot.org/uniprot/#_P30307-mappedCitation-15887239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15887239 |
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| http://purl.uniprot.org/uniprot/B4DX61 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15887239 |
| http://purl.uniprot.org/uniprot/P30307 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15887239 |
| http://purl.uniprot.org/uniprot/Q9H2F0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15887239 |