| http://purl.uniprot.org/citations/15889154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15889154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15889154 | http://www.w3.org/2000/01/rdf-schema#comment | "Polycomb group (PcG) proteins participate in DNA-binding complexes with gene-repressing activity, many of which have been highlighted for their involvement in hematopoiesis. We have identified a putative PcG protein, termed MBT-1, that is associated with Rnf2, an in vivo interactor of PcG proteins. MBT-1 structurally resembles the H-L(3)MBT protein, whose deletion is predicted to be responsible for myeloid hematopoietic malignancies. The human MBT-1 gene is located on chromosome 6q23, a region frequently deleted in leukemia cells, and shows a transient expression spike in response to maturation-inducing stimuli in myeloid leukemia cells. MBT-1(-/-) myeloid progenitor cells exhibit a maturational deficiency but maintain normal proliferative activities. This results in the accumulation of immature myeloid progenitors and hence, a marked decrease of mature myeloid blood cells, causing the MBT-1(-/-) mice to die of anemia during a late embryonic stage. Together, we conclude that MBT-1 specifically regulates the maturational advancement of myeloid progenitor cells during transitions between two developmental stages. We also show that MBT-1 appears to influence myelopoiesis by transiently enhancing p57(KIP2) expression levels."xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600654"xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600654"xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/author | "Arai S."xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/author | "Arai S."xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/author | "Miyazaki T."xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/author | "Miyazaki T."xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/pages | "1863-1873"xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/pages | "1863-1873"xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/title | "Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1."xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/title | "Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1."xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15889154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15889154 |
| http://purl.uniprot.org/citations/15889154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15889154 |
| http://purl.uniprot.org/citations/15889154 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15889154 |
| http://purl.uniprot.org/citations/15889154 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15889154 |
| http://purl.uniprot.org/uniprot/Q8BLB7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15889154 |
| http://purl.uniprot.org/uniprot/P49919#attribution-21EA1D8393F32657C450C7F84C2015AE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15889154 |