| http://purl.uniprot.org/citations/15893615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15893615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15893615 | http://www.w3.org/2000/01/rdf-schema#comment | "Since HLA-A*26 is one of the most common alleles in Asia, where approximately 20% of people have this allele, identification of HIV-1-specific epitopes presented by HLA-A*26 is necessary for studies on the immunopathogenesis of AIDS and vaccine development in Asia. As presented herein, we used the reverse immunogenetics approach to identify HIV-1 epitopes presented by HLA-A*2601, one of the major HLA-A*26 subtypes. We selected 24 HLA-A*2601-binding peptides out of 110 HIV-1 peptides by using a HLA-A*2601 stabilization assay. The ability of these HLA-A*2601-binding peptides to induce peptide-specific CD8(+) T cells was tested by stimulating PBMCs from HIV-1-infected individuals having HLA-A*2601 with these peptides. Four HLA-A*2601-binding peptides induced peptide-specific CD8 T cells. Analysis using HIV-1 recombinant vaccinia-infected C1R-A*2601 cells indicated that these four peptides were HIV-1 epitopes endogenously presented by HLA-A*2601. Two epitope-specific CD8(+) T cells were predominantly detected in HIV-1 infected individuals, suggesting that these epitopes may be useful for vaccine development."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.vaccine.2005.02.022"xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.vaccine.2005.02.022"xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Tokunaga K."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Tokunaga K."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Satoh M."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Satoh M."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Oka S."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Oka S."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Takiguchi M."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Takiguchi M."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Takamiya Y."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/author | "Takamiya Y."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/name | "Vaccine"xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/name | "Vaccine"xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/pages | "3783-3790"xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/pages | "3783-3790"xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/title | "Identification and characterization of HIV-1-specific CD8+ T cell epitopes presented by HLA-A*2601."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/title | "Identification and characterization of HIV-1-specific CD8+ T cell epitopes presented by HLA-A*2601."xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15893615 | http://purl.uniprot.org/core/volume | "23"xsd:string |