| http://purl.uniprot.org/citations/15893726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15893726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15893726 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently reported that Hepatitis C virus (HCV) RNA replication requires one or more geranylgeranylated host proteins. Using a combination of [(3)H]mevalonate labeling, coimmunoprecipitation, and bioinformatic search, we identified a geranylgeranylated host protein required for HCV RNA replication. This protein, FBL2, contains an F box domain and a CAAX motif (CVIL). It forms a stable immunoprecipitable complex with the HCV nonstructural protein 5A (NS5A). The association of FBL2 with NS5A requires the CAAX motif of FBL2, but not the F box. Deletion of the F box created a dominant-negative protein that inhibited replication of HCV RNA when overexpressed in Huh7-K2040 cells; this inhibition was overcome by coexpression of NS5A. siRNA-mediated knockdown of FBL2 mRNA by 70% in Huh7-HP cells reduced HCV RNA by 65%; this reduction was overcome by expression of a cDNA encoding a wobble mutant of FBL2. The current data indicate that geranylgeranylated FBL2 binds to NS5A in a reaction crucial for HCV RNA replication."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.04.004"xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.04.004"xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Gale M. Jr."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Gale M. Jr."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Ye J."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Ye J."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Brown M.S."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Brown M.S."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Goldstein J.L."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Goldstein J.L."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Keller B.C."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/author | "Keller B.C."xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/pages | "425-434"xsd:string |
| http://purl.uniprot.org/citations/15893726 | http://purl.uniprot.org/core/pages | "425-434"xsd:string |