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http://purl.uniprot.org/citations/15893813http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15893813http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

To examine the impact of polymorphism in the androgen-responsive element I region of the prostate-specific antigen (PSA) gene on the serum testosterone level and Gleason score in patients with newly diagnosed, untreated prostate cancer (PCa). High-grade PCa is associated with a low serum testosterone level, and the testosterone level has been negatively correlated with the expression of PSA.

Methods

Endocrine factors (including testosterone, follicle-stimulating hormone, and luteotropic hormone), PSA level, prostate volume, and Gleason score were measured in 134 patients with untreated, biopsy-verified PCa. PSA polymorphism was determined by polymerase chain reaction-based methods using DNA from peripheral blood samples.

Results

Patients with the PSA G/G genotype had lower serum testosterone levels (3.5 +/-1.2 ng/mL) than those with the A/A genotype (4.3 +/-1.6 ng/mL) or the A/G genotype (4.4 +/-1.5 ng/mL). The PSA level in the A/A and A/G genotype groups were significantly lower than that in the G/G genotype group (18.2 +/- 55.0 ng/mL versus 20.5 +/-27.6 ng/mL, P = 0.013). In a multiple logistic regression model, the odds ratio for the G/G polymorphism was significantly increased for Gleason score (odds ratio 2.4, 95% confidence interval 1.6 to 10.4; P = 0.02) and serum testosterone level (odds ratio 0.44, 95% confidence interval 0.36 to 0.94; P = 0.01) relative to genotypes A/A and A/G.

Conclusions

Our results showed that the PSA G/G genotype is associated with a greater Gleason score and serum PSA level but lower serum testosterone level and could be considered a risk factor for a poor outcome of PCa."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.org/dc/terms/identifier"doi:10.1016/j.urology.2004.12.019"xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Micksche M."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Grosser P."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Gsur A."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Haidinger G."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Marberger M."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Schatzl G."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Preyer M."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Zidek T."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Remzi M."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/author"Unterlechner J."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/name"Urology"xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/pages"1141-1145"xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/title"Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer."xsd:string
http://purl.uniprot.org/citations/15893813http://purl.uniprot.org/core/volume"65"xsd:string
http://purl.uniprot.org/citations/15893813http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15893813
http://purl.uniprot.org/citations/15893813http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15893813
http://purl.uniprot.org/uniprot/#_Q15098-mappedCitation-15893813http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15893813
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