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http://purl.uniprot.org/citations/15894356http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

To investigate the biological significance of single nucleotide polymorphism (SNP) at Fas gene promoter in cervical carcinogenesis.

Methods

SNP at -670 of Fas gene promoter (A/G) together with human papillomavirus (HPV) types were examined in a total of 279 cervical smear samples and 8 human cervical squamous carcinoma cell lines using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) techniques.

Results

49 patients with high-grade squamous intraepithelial lesion (HSIL) had higher frequency of high-risk HPV and GA + GG genotype than 167 with low-grade SIL (LSIL) and 63 controls. G allele frequency was also higher in HSIL than in LSIL and controls. There was an increased OR (6.00; CI, 1.32-27.37; P = 0.021) for GA + GG genotype in HSIL cases compared to controls among 96 patients with high-risk HPV. 7 of 8 cervical carcinoma cell lines also showed GA or GG genotype.

Conclusion

Fas gene promoter -670 polymorphism (A/G) may be closely associated with cervical carcinogenesis in a Japanese population."xsd:string
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http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/author"Yamaguchi H."xsd:string
http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/author"Saito J."xsd:string
http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/author"Ueda M."xsd:string
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http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/author"Hung Y.C."xsd:string
http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/author"Ueki M."xsd:string
http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/author"Terai Y."xsd:string
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http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/name"Gynecol Oncol"xsd:string
http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/pages"129-133"xsd:string
http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/title"Fas gene promoter -670 polymorphism (A/G) is associated with cervical carcinogenesis."xsd:string
http://purl.uniprot.org/citations/15894356http://purl.uniprot.org/core/volume"98"xsd:string
http://purl.uniprot.org/citations/15894356http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15894356
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