| http://purl.uniprot.org/citations/15899904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15899904 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclooxygenase and its derived prostaglandin E2 (PGE2) have been shown to stimulate the growth of cancer cells and promote tumor angiogenesis. Here, we show that PGE2 activated the beta-catenin/T cell factor-dependent transcription in colon cancer cells through the cAMP/protein kinase A pathway. The expression of cyclin D1 and vascular endothelial growth factor was induced by PGE2 in LS-174T cells. Moreover, PGE2 and mutated beta-catenin stimulated the transcription of cyclin D1 and vascular endothelial growth factor in a synergistic fashion. Mechanistically, PGE2 increased the phosphorylation of glycogen synthase kinase-3 and consequently accumulated beta-catenin. In addition, PGE2 induced the expression of T cell factor-4 transcription factor, which formed transcriptionally active complex with beta-catenin. In animal experiments, administration of 16,16-dimethyl PGE2 strongly increased the expression of cyclin D1 and vascular endothelial growth factor in APC(min/+) mouse polyps. Thus, our results provide a novel mechanism, suggesting that cyclooxygenase-2/PGE2 may exert pro-oncogenic actions through stimulating the beta-catenin/T cell factor-mediated transcription, which plays critical roles in colorectal carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/15899904 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m413056200"xsd:string |
| http://purl.uniprot.org/citations/15899904 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/15899904 | http://purl.uniprot.org/core/author | "Sheng H."xsd:string |
| http://purl.uniprot.org/citations/15899904 | http://purl.uniprot.org/core/author | "Jung C."xsd:string |
| http://purl.uniprot.org/citations/15899904 | http://purl.uniprot.org/core/author | "Shao J."xsd:string |
| http://purl.uniprot.org/citations/15899904 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15899904 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15899904 | http://purl.uniprot.org/core/pages | "26565-26572"xsd:string |
| http://purl.uniprot.org/citations/15899904 | http://purl.uniprot.org/core/title | "Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer."xsd:string |
| http://purl.uniprot.org/citations/15899904 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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| http://purl.uniprot.org/uniprot/#_E0YMK3-mappedCitation-15899904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15899904 |
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| http://purl.uniprot.org/uniprot/#_E0YMJ0-mappedCitation-15899904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15899904 |
| http://purl.uniprot.org/uniprot/#_E0YMJ1-mappedCitation-15899904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15899904 |
| http://purl.uniprot.org/uniprot/#_E0YMJ2-mappedCitation-15899904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15899904 |
| http://purl.uniprot.org/uniprot/#_E0YMJ3-mappedCitation-15899904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15899904 |
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