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http://purl.uniprot.org/citations/15899957http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15899957http://www.w3.org/2000/01/rdf-schema#comment"

Context

Low birth weight (LBW) is associated with increased risk of type 2 diabetes mellitus. An impaired incretin effect was reported previously in type 2 diabetic patients.

Objective

We studied the secretion and action of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in young LBW men (n = 24) and matched normal birth weight controls (NBW) (n = 25).

Results

LBW subjects were 5 cm shorter but had a body mass index similar to NBW. LBW subjects had significantly elevated fasting and postprandial plasma glucose, as well as postprandial (standard meal test) plasma insulin and C-peptide concentrations, suggestive of insulin resistance. Insulin secretion in response to changes in glucose concentration ("beta-cell responsiveness") during the meal test was similar in LBW and NBW but inappropriate in LBW relative to insulin sensitivity. Fasting and postprandial plasma GLP-1 and GIP levels were similar in the groups. First- and second-phase insulin responses were similar in LBW and NBW during a hyperglycemic clamp (7 mm) with infusion of GLP-1 or GIP, respectively, demonstrating normal action of these hormones on insulin secretion.

Conclusion

Reduced secretion or action of GLP-1 or GIP does not explain a relative reduced beta-cell responsiveness to glucose or the slightly elevated plasma glucose concentrations observed in young LBW men."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.org/dc/terms/identifier"doi:10.1210/jc.2005-0382"xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/author"Jensen C.B."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/author"Holst J.J."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/author"Deacon C.F."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/author"Vaag A.A."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/author"Madsbad S."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/author"Vilsboll T."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/author"Volund A."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/author"Pilgaard K."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/author"Schou J.H."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/pages"4912-4919"xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/title"Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight."xsd:string
http://purl.uniprot.org/citations/15899957http://purl.uniprot.org/core/volume"90"xsd:string
http://purl.uniprot.org/citations/15899957http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15899957
http://purl.uniprot.org/citations/15899957http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15899957
http://purl.uniprot.org/uniprot/#_P09681-mappedCitation-15899957http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15899957
http://purl.uniprot.org/uniprot/P09681http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15899957