| http://purl.uniprot.org/citations/15901746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15901746 | http://www.w3.org/2000/01/rdf-schema#comment | "The objectives of this study were to assess the safety and tolerability of single doses of 1, 4, and 8 mug of recombinant human interleukin-12 (rhIL-12) administered subcutaneously to healthy subjects. The pharmacokinetics, pharmacodynamics, and pharmacogenomics of rhIL-12 were evaluated. Recombinant human IL-12 was well tolerated in these healthy male and female subjects. The most frequently reported adverse events were flu-like symptoms, which exhibited a dose-response relationship. Pharmacokinetic analysis suggested that serum IL-12 levels increased with dose. Analysis of serum levels indicated that interferon-gamma increased with the dose of rhIL-12, whereas IL-6 levels showed no changes with rhIL-12 treatment. The messenger ribonucleic acid expression of signal transducer and activator of transcription was significantly increased 24 hours after the administration of rhIL-12 for all dose groups versus placebo, and results indicated that the magnitude of increase may be dose dependent. This study suggests that interferon-gamma and signal transducer and activator of transcription are biomarkers of rhIL-12 activity."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.org/dc/terms/identifier | "doi:10.1177/0091270005276116"xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Dorner A.J."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Trepicchio W.L."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Van Cleave V.H."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Cotreau M.M."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Strahs A."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Oestreicher J.L."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Dykstra K.H."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Schwertschlag U.S."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Stonis L."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/author | "Trudeau C."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/name | "J Clin Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/pages | "649-658"xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/title | "A single administration of recombinant human interleukin-12 is associated with increased expression levels of interferon-gamma and signal transducer and activator of transcription in healthy subjects."xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/15901746 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15901746 |
| http://purl.uniprot.org/citations/15901746 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15901746 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3SIX0-mappedCitation-15901746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15901746 |
| http://purl.uniprot.org/uniprot/#_A0A510GAH5-mappedCitation-15901746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15901746 |
| http://purl.uniprot.org/uniprot/#_B4DGA4-mappedCitation-15901746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15901746 |
| http://purl.uniprot.org/uniprot/#_A4ZVS7-mappedCitation-15901746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15901746 |
| http://purl.uniprot.org/uniprot/#_A4ZVS8-mappedCitation-15901746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15901746 |