| http://purl.uniprot.org/citations/15905521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15905521 | http://www.w3.org/2000/01/rdf-schema#comment | "The 4-1BB (CD137) is a member of the TNFR superfamily, and is expressed on several cell types, including activated T cells. Although 4-1BB ligation by agonistic Ab or 4-1BB ligand-expressing APCs can costimulate T cells, the physiological significance of 4-1BB expression in vivo during T cell responses is still being elucidated. In this study, we have addressed the impact on CD4 T cell priming when 4-1BB is absent after gene targeting. Surprisingly, 4-1BB(-/-) mice generated more enhanced effector CD4 T cell responses to OVA protein in adjuvant, even though Ab responses in 4-1BB(-/-) mice were normal. Using an adoptive transfer system with OT-II TCR transgenic CD4 T cells, we found that 4-1BB(-/-) CD4 cells responding in a 4-1BB-sufficient environment had enhanced cell division compared with wild-type cells and displayed augmented clonal expansion during the primary response. This was not due to a developmental defect as 4-1BB-deficient CD4 cells could respond normally to Ag in vitro. These results demonstrate that the absence of 4-1BB can make CD4 T cells hyperresponsive to protein Ag in vivo, suggesting a new unappreciated negative regulatory role of 4-1BB when expressed on a T cell."xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.11.6803"xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://purl.uniprot.org/core/author | "Croft M."xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://purl.uniprot.org/core/author | "Vella A.T."xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://purl.uniprot.org/core/author | "Kwon B.S."xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15905521 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://purl.uniprot.org/core/pages | "6803-6808"xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://purl.uniprot.org/core/title | "Enhanced CD4 T cell responsiveness in the absence of 4-1BB."xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15905521 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15905521 |
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