| http://purl.uniprot.org/citations/15907477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15907477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15907477 | http://www.w3.org/2000/01/rdf-schema#comment | "Adenovirus early region 1B-associated protein 5, E1B-AP5, a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, was originally isolated on the basis of its ability to bind to the adenovirus 5 early region1B55K protein. Here, it has been demonstrated that E1B-AP5 interacts with mutant and wild-type p53 from human cells in pull-down assays using GST-E1B-AP5. This interaction has been confirmed by co-immunoprecipitation studies and pull-down experiments with in vitro translated E1B-AP5 and GST-p53. The binding site for E1B-AP5 has been mapped to the C-terminal region of p53. In reciprocal experiments, it has been shown that several regions of E1B-AP5 bound to p53 although it is probable that a major site of interaction is located between amino acids 395 and 732 of E1B-AP5. In reporter assays, E1B-AP5 inhibited p53 transcriptional activity although not as efficiently as the Ad5E1B55K protein. Transfection of E1B-AP5 into human tumour cells affected the cellular response to UV radiation, such that, although p53 expression was induced, little change in the level of p53-inducible genes could be observed."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.03.095"xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.03.095"xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Dobner T."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Dobner T."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Turnell A.S."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Turnell A.S."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Byrd P.J."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Byrd P.J."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Gallimore P.H."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Gallimore P.H."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Rusch A."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Rusch A."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Barral P.M."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Barral P.M."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Grand R.J."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/author | "Grand R.J."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/pages | "2752-2758"xsd:string |
| http://purl.uniprot.org/citations/15907477 | http://purl.uniprot.org/core/pages | "2752-2758"xsd:string |