| http://purl.uniprot.org/citations/15909309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15909309 | http://www.w3.org/2000/01/rdf-schema#comment | "During B cell development, proliferative expansion takes place after expression of the pre-BCR. At this pre-BII cell stage, the IL-7Ralpha is also expressed. Some in vitro studies suggest that pre-BCR-dependent expansion relies on the IL-7Ralpha, and others that it does not. It has also been suggested that the pre-BCR mediates down-regulation of the IL-7Ralpha. However, the in vivo relationship between the pre-BCR and the IL-7Ralpha has not been previously examined. Here, we have investigated this by establishing mice lacking both receptors. Our results show that in the absence of the IL-7Ralpha, the pre-BII population is reduced, as previously seen in mice lacking the pre-BCR, demonstrating that the IL-7Ralpha is important at this stage. A deficiency in both receptors results in a further reduction of the pre-BII cell population. We conclude that both the IL-7Ralpha and the pre-BCR are required for optimal pre-BII cell expansion. Furthermore, IL-7Ralpha expression levels are normal in pre-BCR-deficient mice, suggesting that the pre-BCR does not mediate its down-regulation. As a consequence of the absence of both receptors, the peripheral B cell pool is severely depleted, resulting in atypical splenic B cell structures and reduced serum Ig levels."xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200425821"xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/author | "Lane P."xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/author | "Erlandsson L."xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/author | "Martensson I.L."xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/author | "Corcoran A.E."xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/author | "Licence S."xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/author | "Gaspal F."xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/pages | "1969-1976"xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/title | "Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo."xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/15909309 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15909309 |
| http://purl.uniprot.org/citations/15909309 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15909309 |
| http://purl.uniprot.org/uniprot/P25918#attribution-6709F3B6AF959927323D7F98036182B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15909309 |
| http://purl.uniprot.org/uniprot/P19070#attribution-6709F3B6AF959927323D7F98036182B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15909309 |
| http://purl.uniprot.org/uniprot/P20693#attribution-6709F3B6AF959927323D7F98036182B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15909309 |
| http://purl.uniprot.org/uniprot/P01872#attribution-6709F3B6AF959927323D7F98036182B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15909309 |
| http://purl.uniprot.org/uniprot/P16872#attribution-4DDD0676C295D3C54083567C7F0AD0BB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15909309 |
| http://purl.uniprot.org/uniprot/P16872#attribution-6709F3B6AF959927323D7F98036182B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15909309 |
| http://purl.uniprot.org/uniprot/P16872#attribution-A5926B01B1152886111DECC1313B2D29 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15909309 |
| http://purl.uniprot.org/uniprot/P01590#attribution-6709F3B6AF959927323D7F98036182B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15909309 |
| http://purl.uniprot.org/uniprot/P05532#attribution-6709F3B6AF959927323D7F98036182B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15909309 |