| http://purl.uniprot.org/citations/15909310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15909310 | http://www.w3.org/2000/01/rdf-schema#comment | "The structure of immunological synapses formed between murine naive T cells and mature dendritic cells has been subjected to a quantitative analysis. Immunofluorescence images of synapses formed in the absence of antigen show a diffuse synaptic accumulation of CD3 and LFA-1. In electron microscopy, these antigen-free synapses present a number of tight appositions (cleft size approximately 15 nm), all along the synapse. These tight appositions cover a significantly larger surface fraction of antigen-dependent synapses. In immunofluorescence, antigen-dependent synapses show multiple patches of CD3 and LFA-1 with a variable overlap. A similar distribution is observed for PKCtheta and talin. A concentric organization characteristic of prototypical synapses is rarely observed, even when dendritic cells are paralyzed by cytoskeletal poisons. In T-DC synapses, the interaction surface is composed of several tens of submicronic contact spots, with no large-scale segregation of CD3 and LFA-1. As a comparison, in T-B synapses, a central cluster of CD3 is frequently observed by immunofluorescence, and electron microscopy reveals a central tight apposition. Our data show that it is inappropriate to consider the concentric structure as a "mature synapse" and multifocal structures as immature."xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200425857"xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/author | "Schmitt A."xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/author | "Raposo G."xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/author | "Romao M."xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/author | "Randriamampita C."xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/author | "Trautmann A."xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/author | "Brossard C."xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/author | "Feuillet V."xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/pages | "1741-1753"xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/title | "Multifocal structure of the T cell - dendritic cell synapse."xsd:string |
| http://purl.uniprot.org/citations/15909310 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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